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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
4.55
Human Site:
T636
Identified Species:
7.14
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
T636
Q
Q
P
S
R
N
V
T
T
K
N
Y
S
E
V
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
T636
Q
Q
P
S
R
N
V
T
T
K
N
Y
S
E
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
A636
Q
Q
P
S
R
N
V
A
T
K
N
Y
S
E
V
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
A635
Q
Q
P
S
R
N
V
A
P
K
N
Y
S
E
T
Rat
Rattus norvegicus
Q9JIM0
706
80103
A635
Q
Q
P
S
R
N
V
A
T
K
N
Y
S
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
P635
F
K
S
T
R
Q
Q
P
T
R
N
V
A
T
K
Chicken
Gallus gallus
Q9IAM7
700
80005
Q629
S
L
K
P
E
P
S
Q
S
T
S
K
F
F
S
Frog
Xenopus laevis
Q9W6K1
711
81112
A633
Q
P
T
A
R
N
V
A
K
K
T
Y
S
E
D
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
D547
D
D
D
L
G
L
S
D
D
P
A
D
I
A
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
G546
E
K
S
M
S
V
L
G
S
E
V
N
V
S
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
E643
D
E
V
A
N
S
D
E
E
M
G
S
S
I
S
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
L444
E
T
K
Q
L
E
L
L
S
E
K
G
L
G
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
D634
S
E
E
V
E
P
E
D
F
N
K
P
D
S
S
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
D621
N
E
L
G
D
N
N
D
A
Q
D
D
V
D
I
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
E656
V
D
S
D
E
E
E
E
E
D
Y
P
E
D
D
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
93.3
N.A.
80
86.6
N.A.
20
0
53.3
0
N.A.
0
N.A.
6.6
0
P-Site Similarity:
100
100
N.A.
93.3
N.A.
80
86.6
N.A.
46.6
13.3
60
6.6
N.A.
33.3
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
40
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
14
0
0
0
27
7
0
7
0
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
14
7
7
7
0
7
20
7
7
7
14
7
14
14
% D
% Glu:
14
20
7
0
20
14
14
14
14
14
0
0
7
40
0
% E
% Phe:
7
0
0
0
0
0
0
0
7
0
0
0
7
7
0
% F
% Gly:
0
0
0
7
7
0
0
7
0
0
7
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
7
% I
% Lys:
0
14
14
0
0
0
0
0
7
40
14
7
0
0
7
% K
% Leu:
0
7
7
7
7
7
14
7
0
0
0
0
7
0
0
% L
% Met:
0
0
0
7
0
0
0
0
0
7
0
0
0
0
7
% M
% Asn:
7
0
0
0
7
47
7
0
0
7
40
7
0
0
0
% N
% Pro:
0
7
34
7
0
14
0
7
7
7
0
14
0
0
0
% P
% Gln:
40
34
0
7
0
7
7
7
0
7
0
0
0
0
7
% Q
% Arg:
0
0
0
0
47
0
0
0
0
7
0
0
0
0
0
% R
% Ser:
14
0
20
34
7
7
14
0
20
0
7
7
47
14
20
% S
% Thr:
0
7
7
7
0
0
0
14
34
7
7
0
0
7
20
% T
% Val:
7
0
7
7
0
7
40
0
0
0
7
7
14
0
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
40
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _